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RNase Buffer: Complete Scientific Guide for RNA Protection and Stability What Is RNase Buffer? An RNase buffer is a specialized solution designed to protect RNA molecules from degradation by ribonucleases (RNases), which are highly stable and ubiquitous enzymes that rapidly break down RNA. Because RNA is extremely sensitive and prone to degradation, using an effective RNase buffer is essential in molecular biology workflows such as RNA extraction, RT-PCR, and sequencing. Why RNase Buffer Is Esse …