CleaScrip™ T7 RNA Polymerase (Low dsRNA, 250 U/μL) – 10 KU

CleaScrip™ T7 RNA Polymerase (Low dsRNA, 250 U/μL) – 10 KU

Product Overview

CleaScrip™ T7 RNA Polymerase is a high-performance, engineered enzyme designed for in vitro transcription (IVT) applications requiring ultra-low double-stranded RNA (dsRNA) contamination. This advanced polymerase enables the synthesis of high-quality RNA with significantly reduced immunogenic by-products, making it ideal for sensitive downstream applications such as mRNA therapeutics, vaccines, and gene expression studies.

Optimized for efficiency and fidelity, CleaScrip™ ensures robust RNA yield while minimizing dsRNA formation, a critical factor in improving the safety and performance of RNA-based workflows.

SHOP NOW 

Key Features

  • Ultra-low dsRNA production: Minimizes innate immune activation
  • High transcription efficiency: Generates large amounts of RNA rapidly
  • High purity RNA output: Suitable for therapeutic and research applications
  • Optimized for IVT workflows: Compatible with standard transcription protocols
  • Concentration: 250 U/μL for flexible reaction setup

Applications

  • mRNA vaccine development
  • In vitro transcription (IVT)
  • Gene expression and functional studies
  • RNA therapeutics and drug development
  • CRISPR guide RNA synthesis

Technical Specifications

Parameter Specification
Product Name CleaScrip™ T7 RNA Polymerase
Enzyme Type T7 RNA Polymerase
Concentration 250 U/μL
Total Units 10 KU
dsRNA Content Ultra-low
Storage -20°C
Format Liquid

    Product Description

    Traditional T7 RNA polymerases often generate unwanted double-stranded RNA (dsRNA) during transcription, which can trigger immune responses in sensitive systems. CleaScrip™ overcomes this limitation through advanced enzyme engineering, significantly reducing dsRNA contamination while maintaining high transcriptional activity.

    This makes it particularly valuable in mRNA-based applications, where RNA purity directly impacts translation efficiency and biological outcomes.

    Advantages Over Standard T7 Polymerase

    • Reduced dsRNA → improved translational efficiency
    • Lower immunogenicity in cell-based systems
    • Enhanced reproducibility in IVT reactions
    • Ideal for clinical and preclinical research

    Storage & Handling

    • Store at -20°C
    • Avoid repeated freeze-thaw cycles
    • Keep on ice during use

    Quality Assurance

    Each batch of CleaScrip™ T7 RNA Polymerase undergoes rigorous quality control to ensure:

    • High enzymatic activity
    • Minimal dsRNA contamination
    • Lot-to-lot consistency

    Why Choose CleaScrip™?

    CleaScrip™ is specifically designed for researchers working on next-generation RNA technologies, offering a reliable solution for producing high-purity RNA with minimal immune activation risk.